Brain Metastases From Melanoma
نویسندگان
چکیده
منابع مشابه
hemorrhagic brain metastases as a manifestation of metastatic malignant melanoma.
#no abstract#
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Melanoma brain metastases (MBM) present a significant clinical challenge. Molecular profiling of MBM is useful to identify molecular pathways, such as the PI3K pathway, that are specifically and differentially altered in MBM. Therapeutic studies should recruit patients with MBM and prospective tissue collection will lay the foundation for further advances.
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Purpose: The objective of this study is to report the combined experience at Johns Hopkins University (JHU) and the Miami Neuroscience Center (MNC) in treating brain metastases from melanoma with stereotactic radiosurgery (SRS). Methods and Materials: Prospectively collected clinical and demographic data on patients with melanoma treated with Gamma Knife (GK) at JHU between 2003 and 2007 and th...
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BACKGROUND The development of brain metastases is common in patients with melanoma and is associated with a poor prognosis. Treating patients with melanoma brain metastases (MBMs) is a major therapeutic challenge. Standard approaches with conventional chemotherapy are disappointing, while surgery and radiotherapy have improved outcomes. METHODS In this article, we discuss the biology of MBMs,...
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Patients with brain metastases from malignant melanoma historically have a very poor outcome. Surgery and radiotherapy can be used, but for the majority of patients the disease will progress quickly. In the recent past, patients with brain metastases derived only minimal benefit from cytotoxic chemotherapy. Novel therapies that have been shown to be superior to chemotherapy in metastatic melano...
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ژورنال
عنوان ژورنال: American Journal of Clinical Oncology
سال: 2010
ISSN: 0277-3732
DOI: 10.1097/coc.0b013e3181c4c54b